BDBM103777 US8551978, I-47::US8816088, I-47::US9394275, I-47::US9572802, Compound I-47::US9682957, I-47

SMILES CC(Cc1ccc(CNC(=O)c2ccc(C)c(c2)N(C)C(=O)CCN2CCC(CC2)OC(=O)Nc2ccccc2-c2ccccc2)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12

InChI Key InChIKey=ODECJHUQVYAWEN-LYMXURKRSA-N

Data  5 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 103777   

TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Theravance

US Patent
LigandPNGBDBM103777(US8551978, I-47 | US8816088, I-47 | US9394275, I-4...)
Affinity DataKi:  0.200nMAssay Description:Radioligand binding assay using muscarinic receptors.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Theravance

US Patent
LigandPNGBDBM103777(US8551978, I-47 | US8816088, I-47 | US9394275, I-4...)
Affinity DataKi:  0.200nMAssay Description:Radioligand binding assays for cloned muscarinic receptors were performed in 96-well microtiter plates in a total assay volume of 100 uL. CHO cell me...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Theravance

US Patent
LigandPNGBDBM103777(US8551978, I-47 | US8816088, I-47 | US9394275, I-4...)
Affinity DataKi:  0.200nM ΔG°:  -13.8kcal/moleT: 2°CAssay Description:Displacement assays for determination of Ki values of test compounds were performed with [3H]-NMS at 1 nM and eleven different test compound concentr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Theravance

US Patent
LigandPNGBDBM103777(US8551978, I-47 | US8816088, I-47 | US9394275, I-4...)
Affinity DataKi:  0.200nMAssay Description:compounds were performed with [3H]NMS at 1 nM and eleven different test compound concentrations. The test compounds were initially dissolved to a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Theravance

US Patent
LigandPNGBDBM103777(US8551978, I-47 | US8816088, I-47 | US9394275, I-4...)
Affinity DataKi:  0.200nMAssay Description:Radioligand binding assays for cloned muscarinic receptors were performed in 96-well microtiter plates in a total assay volume of 100 μL. CHO ce...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Theravance Respiratory

US Patent
LigandPNGBDBM103777(US8551978, I-47 | US8816088, I-47 | US9394275, I-4...)
Affinity DataEC50:  3nMT: 2°CAssay Description:cAMP assays were performed in a radioimmunoassay format using the Flashplate Adenylyl Cyclase Activation Assay System with [125I]-cAMP (NEN SMP004, P...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Theravance Respiratory

US Patent
LigandPNGBDBM103777(US8551978, I-47 | US8816088, I-47 | US9394275, I-4...)
Affinity DataEC50:  3nMT: 2°CAssay Description:cAMP assays were performed in a radioimmunoassay format using the Flashplate Adenylyl Cyclase Activation Assay System with [125I]-cAMP (NEN SMP004, P...More data for this Ligand-Target Pair
In DepthDetails US Patent