BDBM10487 1-chloro-6H,7H,8H,9H,10H-cyclohepta[b]quinolin-11-amine::11-Amino-1-chloro-6H-cyclohepta[b]quinoline::Tacrine (THA) analogue 2

SMILES Nc1c2CCCCCc2nc2cccc(Cl)c12

InChI Key InChIKey=KAAAIHLOSOSBCH-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 10487   

TargetAcetylcholinesterase(Tetronarce californica (Pacific electric ray) (Tor...)
Syngenta

LigandPNGBDBM10487(1-chloro-6H,7H,8H,9H,10H-cyclohepta[b]quinolin-11-...)
Affinity DataIC50:  2.40nMpH: 7.8 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM10487(1-chloro-6H,7H,8H,9H,10H-cyclohepta[b]quinolin-11-...)
Affinity DataIC50:  2.23E+5nMAssay Description:Inhibition of human recombinant AChE assessed as reduction in cholinesterase activity using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM10487(1-chloro-6H,7H,8H,9H,10H-cyclohepta[b]quinolin-11-...)
Affinity DataIC50:  311nMAssay Description:Inhibition of human plasmatic BuChE assessed as reduction in cholinesterase activity by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Rattus norvegicus (Rat))
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM10487(1-chloro-6H,7H,8H,9H,10H-cyclohepta[b]quinolin-11-...)
Affinity DataIC50:  1.46E+5nMAssay Description:Inhibition of human GluN1a/GluN2B receptor expressed in HEK293 cells assessed as relative inhibition of glycine/glutamate-induced current measured at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Rattus norvegicus (Rat))
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM10487(1-chloro-6H,7H,8H,9H,10H-cyclohepta[b]quinolin-11-...)
Affinity DataIC50:  2.21E+4nMAssay Description:Inhibition of human GluN1a/GluN2B receptor expressed in HEK293 cells assessed as inhibition of glycine/glutamate-induced current measured at -60 mV h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM10487(1-chloro-6H,7H,8H,9H,10H-cyclohepta[b]quinolin-11-...)
Affinity DataIC50:  1.12E+5nMAssay Description:Inhibition of human GluN1a/GluN2A receptor expressed in HEK293 cells assessed as relative inhibition of glycine/glutamate-induced current measured at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM10487(1-chloro-6H,7H,8H,9H,10H-cyclohepta[b]quinolin-11-...)
Affinity DataIC50:  7.29E+3nMAssay Description:Inhibition of human GluN1a/GluN2A receptor expressed in HEK293 cells assessed as inhibition of glycine/glutamate-induced current measured at -60 mV h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed