BDBM106221 US9695174, Ko134

SMILES CC(C)C[C@@H]1N2[C@@H](Cc3c1[nH]c1ccccc31)C(=O)N[C@@H](CCC(=O)OC(C)(C)C)C2=O

InChI Key

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 106221   

TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM106221(US9695174, Ko134)
Affinity DataIC50:  3.25E+3nMpH: 7.4 T: 2°CAssay Description:To determine potency of compounds on inhibition of transporters, bi-directional transport studies are performed in Caco-2 cells (American Type Cultur...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM106221(US9695174, Ko134)
Affinity DataIC50:  230nMAssay Description:Inhibition of BCRP in human Caco2 cells using 3H-Estron-3-sulfate as substrate assessed as Ko143 IC50 measured at 30 to 120 mins by microplate scinti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM106221(US9695174, Ko134)
Affinity DataIC50:  3.25E+3nMAssay Description:Inhibition of BCRP in human Caco2 cells using 3H-Estron-3-sulfate as substrate measured at 30 to 120 mins by microplate scintillation and luminescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed