BDBM10727 3-amino-2,3-dihydro-1H-inden-5-yl N,N-dimethylcarbamate::Aminoindan deriv. 7a

SMILES CN(C)C(=O)Oc1ccc2CCC(N)c2c1

InChI Key InChIKey=QZQSLQIZEWMPQS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 10727   

TargetAcetylcholinesterase(Homo sapiens (Human))
Teva Pharmaceutical Industries

LigandPNGBDBM10727(3-amino-2,3-dihydro-1H-inden-5-yl N,N-dimethylcarb...)
Affinity DataIC50:  760nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Teva Pharmaceutical Industries

LigandPNGBDBM10727(3-amino-2,3-dihydro-1H-inden-5-yl N,N-dimethylcarb...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of MAO activity was determined by a radiometric procedure from Tipton and Youdim. Homogenized rat brain was used as the source of enzymes....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
Teva Pharmaceutical Industries

LigandPNGBDBM10727(3-amino-2,3-dihydro-1H-inden-5-yl N,N-dimethylcarb...)
Affinity DataIC50:  8.00E+4nMAssay Description:Inhibition of MAO activity was determined by a radiometric procedure from Tipton and Youdim. Homogenized rat brain was used as the source of enzymes....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Teva Pharmaceutical Industries

LigandPNGBDBM10727(3-amino-2,3-dihydro-1H-inden-5-yl N,N-dimethylcarb...)
Affinity DataIC50:  630nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed