BDBM10799 (3R)-3-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-inden-5-ol::6-hydroxy-N-propargyl-1(R)-aminoindan::Aminoindan deriv. (R)39u::CHEMBL371428::R-HPAI::rasagiline analogue

SMILES Oc1ccc2CC[C@@H](NCC#C)c2c1

InChI Key InChIKey=NRSDGDXUWMMUEV-GFCCVEGCSA-N

Data  3 KI  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 10799   

TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Emory University

LigandPNGBDBM10799((3R)-3-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-inden-...)
Affinity DataKi:  1.90E+3nM ΔG°:  -7.80kcal/molepH: 7.5 T: 2°CAssay Description:MAO A and MAO B activities were determined spectrophotometrically at 316 nm and 250 nm using kynuramine and benzylamine as substrates, respectively. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Emory University

LigandPNGBDBM10799((3R)-3-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-inden-...)
Affinity DataKi:  1.70E+4nM ΔG°:  -6.50kcal/molepH: 7.5 T: 2°CAssay Description:MAO A and MAO B activities were determined spectrophotometrically at 316 nm and 250 nm using kynuramine and benzylamine as substrates, respectively. ...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Emory University

LigandPNGBDBM10799((3R)-3-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-inden-...)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition constant against human recombinant Monoamine oxidase-B More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Teva Pharmaceutical Industries

LigandPNGBDBM10799((3R)-3-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-inden-...)
Affinity DataIC50:  230nMAssay Description:Inhibition of MAO activity was determined by a radiometric procedure from Tipton and Youdim. Homogenized rat brain was used as the source of enzymes....More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
Teva Pharmaceutical Industries

LigandPNGBDBM10799((3R)-3-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-inden-...)
Affinity DataIC50:  300nMAssay Description:Inhibition of MAO activity was determined by a radiometric procedure from Tipton and Youdim. Homogenized rat brain was used as the source of enzymes....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed