Found 171 hits for monomerid = 10849 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar
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| DrugBank Article PubMed
| n/a | n/a | n/a | 4.50E+4 | n/a | n/a | n/a | n/a | n/a |
University of Ferrara
Curated by ChEMBL
| Assay Description Dissociation constant against Adenosine A1 receptor |
J Med Chem 48: 2026-35 (2005)
Article DOI: 10.1021/jm040842z BindingDB Entry DOI: 10.7270/Q2J67HQX |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
Reactome pathway KEGG
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| Article PubMed
| 1.88E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membrane |
Eur J Med Chem 46: 3590-607 (2011)
Article DOI: 10.1016/j.ejmech.2011.05.023 BindingDB Entry DOI: 10.7270/Q2ZC840S |
More data for this Ligand-Target Pair | |
Adenosine Receptors A2a (A2a)
(Rattus norvegicus (rat)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB MMDB
Reactome pathway KEGG
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| PDB Article PubMed
| 3.28E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]MSX-2 from adenosine A2A receptor in rat brain striatal membrane |
Eur J Med Chem 46: 3590-607 (2011)
Article DOI: 10.1016/j.ejmech.2011.05.023 BindingDB Entry DOI: 10.7270/Q2ZC840S |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
Reactome pathway KEGG
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| DrugBank Article PubMed
| 4.49E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells |
Eur J Med Chem 46: 3590-607 (2011)
Article DOI: 10.1016/j.ejmech.2011.05.023 BindingDB Entry DOI: 10.7270/Q2ZC840S |
More data for this Ligand-Target Pair | |
Adenosine receptor A2a
(Homo sapiens (Human)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
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| DrugBank PDB Article PubMed
| 2.34E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]MSX-2 from human recombinant adenosine A2A receptor expressed in CHO cells |
Eur J Med Chem 46: 3590-607 (2011)
Article DOI: 10.1016/j.ejmech.2011.05.023 BindingDB Entry DOI: 10.7270/Q2ZC840S |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Adenosine receptor A2b
(Homo sapiens (Human)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | NCI pathway Reactome pathway KEGG
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| Article PubMed
| 2.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells |
Eur J Med Chem 46: 3590-607 (2011)
Article DOI: 10.1016/j.ejmech.2011.05.023 BindingDB Entry DOI: 10.7270/Q2ZC840S |
More data for this Ligand-Target Pair | |
Adenosine receptor A3
(Homo sapiens (Human)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | Reactome pathway KEGG
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| Article PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]PSB-11 from human recombinant adenosine A3 receptor expressed in CHO cells |
Eur J Med Chem 46: 3590-607 (2011)
Article DOI: 10.1016/j.ejmech.2011.05.023 BindingDB Entry DOI: 10.7270/Q2ZC840S |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB MMDB
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| Article PubMed
| n/a | n/a | 4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TCG Lifesciences Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human ERG |
Eur J Med Chem 46: 618-30 (2011)
Article DOI: 10.1016/j.ejmech.2010.11.042 BindingDB Entry DOI: 10.7270/Q2WQ052W |
More data for this Ligand-Target Pair | |
Endochitinase B1
(Aspergillus fumigatus) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB MMDB
KEGG
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| PDB Article PubMed
| n/a | n/a | 4.69E+5 | n/a | n/a | n/a | n/a | 5.5 | 37 |
University of Dundee
| Assay Description The IC50s of inhibitor against the human chitinase were determined using the fluorogenic substrate 4MU-NAG3. The fluorescence of the liberated 4MU wa... |
Chem Biol 12: 973-80 (2005)
Article DOI: 10.1016/j.chembiol.2005.07.009 BindingDB Entry DOI: 10.7270/Q2765CJG |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB MMDB
Reactome pathway KEGG
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| DrugBank Article PubMed
| n/a | n/a | 7.47E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Dundee
| Assay Description Phosphodiesterase 4A (PDE4A) was assayed using an Sf9-expressed GST-fusion, and activity was monitored by hydrolysis of [3H]cAMP to [3H]AMP using the... |
Chem Biol 12: 973-80 (2005)
Article DOI: 10.1016/j.chembiol.2005.07.009 BindingDB Entry DOI: 10.7270/Q2765CJG |
More data for this Ligand-Target Pair |  3D Structure (docked) |
Chitinase 1
(Homo sapiens (Human)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 2.57E+5 | n/a | n/a | n/a | n/a | 5.5 | 30 |
University of Dundee
| Assay Description The IC50s of inhibitor against the human chitinase were determined using the fluorogenic substrate 4MU-NAG3. The fluorescence of the liberated 4MU wa... |
Chem Biol 12: 973-80 (2005)
Article DOI: 10.1016/j.chembiol.2005.07.009 BindingDB Entry DOI: 10.7270/Q2765CJG |
More data for this Ligand-Target Pair | |
Glycogen phosphorylase, muscle form
(Oryctolagus cuniculus (rabbit)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB MMDB
KEGG
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| PDB Article PubMed
| n/a | n/a | 1.14E+5 | n/a | n/a | n/a | n/a | 7.2 | 22 |
China Pharmaceutical University
| Assay Description The activity of the compounds is determined by measuring the inhibitory effect of the compounds in the direction of glycogen synthesis, the conversio... |
J Med Chem 51: 3540-54 (2008)
Article DOI: 10.1021/jm8000949 BindingDB Entry DOI: 10.7270/Q2WQ0233 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
Reactome pathway KEGG
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| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 330: 212-21 (1985)
Article DOI: 10.1007/bf00572436 BindingDB Entry DOI: 10.7270/Q2RB7334 |
More data for this Ligand-Target Pair | |
Adenosine A1 receptor
(BOVINE) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
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Patents
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| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 330: 212-21 (1985)
Article DOI: 10.1007/bf00572436 BindingDB Entry DOI: 10.7270/Q2RB7334 |
More data for this Ligand-Target Pair | |
Adenosine receptor A2a
(Homo sapiens (Human)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
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| DrugBank PDB Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 330: 212-21 (1985)
Article DOI: 10.1007/bf00572436 BindingDB Entry DOI: 10.7270/Q2RB7334 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
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| PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert/Parke-Davis Pharmaceutical Research
Curated by PDSP Ki Database
| |
Mol Pharmacol 29: 331-46 (1986)
BindingDB Entry DOI: 10.7270/Q2MK6BDV |
More data for this Ligand-Target Pair | |
Adenosine receptor A2a
(Homo sapiens (Human)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
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| DrugBank PDB PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert/Parke-Davis Pharmaceutical Research
Curated by PDSP Ki Database
| |
Mol Pharmacol 29: 331-46 (1986)
BindingDB Entry DOI: 10.7270/Q2MK6BDV |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
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| DrugBank Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hokkaido University
Curated by PDSP Ki Database
| |
Bioorg Med Chem 15: 3235-40 (2007)
Article DOI: 10.1016/j.bmc.2007.02.043 BindingDB Entry DOI: 10.7270/Q28G8J9M |
More data for this Ligand-Target Pair | |
Adenosine receptor A2a
(Homo sapiens (Human)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB MMDB
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| DrugBank PDB Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hokkaido University
Curated by PDSP Ki Database
| |
Bioorg Med Chem 15: 3235-40 (2007)
Article DOI: 10.1016/j.bmc.2007.02.043 BindingDB Entry DOI: 10.7270/Q28G8J9M |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Glycogen phosphorylase, muscle form
(Oryctolagus cuniculus (rabbit)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | 1.44E+5 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Institute of Traditional Chinese Medicine, Chengde Medical University, Chengde, 067000, China
| Assay Description Rabbit muscle glycogen phosphorylase a (RMGPa) activity was measured by the release of phosphate from glucose-1-phosphate at 655 nm. Each compound wa... |
Chem Biol Drug Des 83: 297-305 (2014)
Article DOI: 10.1111/cbdd.12241 BindingDB Entry DOI: 10.7270/Q2TH8KBS |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Twik-RElated Potassium (K+) channel 1 (TREK1)
(Homo sapiens (Human)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
Reactome pathway
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| Article PubMed
| n/a | n/a | n/a | n/a | 3.77E+5 | n/a | n/a | 7.3 | 22 |
Korea Institute of Science and Technology
| Assay Description The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ... |
Chem Biol Drug Des 88: 807-819 (2016)
Article DOI: 10.1111/cbdd.12810 BindingDB Entry DOI: 10.7270/Q2S181B1 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 1
(Homo sapiens (Human)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 5.50E+7 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GITAM University
| Assay Description An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes as repo... |
J Enzyme Inhib Med Chem 27: 97-100 (2012)
Article DOI: 10.3109/14756366.2011.578393 BindingDB Entry DOI: 10.7270/Q2HH6HZG |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 2
(Homo sapiens (Human)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB MMDB
Reactome pathway KEGG
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Patents
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| Article PubMed
| n/a | n/a | 2.00E+6 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GITAM University
| Assay Description An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes as repo... |
J Enzyme Inhib Med Chem 27: 97-100 (2012)
Article DOI: 10.3109/14756366.2011.578393 BindingDB Entry DOI: 10.7270/Q2HH6HZG |
More data for this Ligand-Target Pair | |
Adenosine A1 receptor
(GUINEA PIG) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
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| Article PubMed
| 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd
Curated by ChEMBL
| Assay Description Binding affinity against adenosine A1 receptor from guinea pig forebrain membranes, using N6-[3H]-cyclohexyladenosine as radioligand. |
J Med Chem 35: 2342-5 (1992)
Article DOI: 10.1021/jm00090a027 BindingDB Entry DOI: 10.7270/Q2T43S20 |
More data for this Ligand-Target Pair | |
Adenosine A2 receptor
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
Reactome pathway
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| PDB Article PubMed
| 4.81E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of N-[3H]-ethyladenosin-5''-uronamide binding to adenosine A2 receptor from rat striatal membranes |
J Med Chem 35: 2342-5 (1992)
Article DOI: 10.1021/jm00090a027 BindingDB Entry DOI: 10.7270/Q2T43S20 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
Reactome pathway KEGG
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| Article PubMed
| 2.91E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of N6-[3H]-cyclohexyladenosine binding to adenosine A1 receptor from whole brain membranes |
J Med Chem 35: 2342-5 (1992)
Article DOI: 10.1021/jm00090a027 BindingDB Entry DOI: 10.7270/Q2T43S20 |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
Reactome pathway KEGG
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| Article PubMed
| 5.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes
Curated by ChEMBL
| Assay Description Binding affinity for Adenosine A1 receptor from rat brain using [3H]-PIA as radioligand |
J Med Chem 33: 2818-21 (1990)
Article DOI: 10.1021/jm00172a022 BindingDB Entry DOI: 10.7270/Q2C53JVQ |
More data for this Ligand-Target Pair | |
Adenosine A1 receptor
(GUINEA PIG) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
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| Article PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of [3H]-cyclohexyladenosine binding to guinea pig forebrain membranes Adenosine A1 receptor |
J Med Chem 34: 466-9 (1991)
Article DOI: 10.1021/jm00105a072 BindingDB Entry DOI: 10.7270/Q2154G0Z |
More data for this Ligand-Target Pair | |
Adenosine A2 receptor
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
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| PDB Article PubMed
| 3.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institutes of Health
Curated by ChEMBL
| Assay Description Inhibition of 1 nM [3H]- N6 -(phenylisopropyl) adenosine binding to Adenosine A1 receptor in rat fat cell membrane |
J Med Chem 32: 1231-7 (1989)
Article DOI: 10.1021/jm00126a014 BindingDB Entry DOI: 10.7270/Q2PZ57T1 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
Reactome pathway KEGG
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| Article PubMed
| 4.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institutes of Health
Curated by ChEMBL
| Assay Description Inhibition of 1 nM [3H]- N6 -(phenylisopropyl) adenosine binding to Adenosine A1 receptor in rat fat cell membrane |
J Med Chem 32: 1231-7 (1989)
Article DOI: 10.1021/jm00126a014 BindingDB Entry DOI: 10.7270/Q2PZ57T1 |
More data for this Ligand-Target Pair | |
Adenosine receptor
(Rattus norvegicus (rat)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
Reactome pathway KEGG
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| Article PubMed
| 5.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institutes of Health
Curated by ChEMBL
| Assay Description Inhibition of 1 nM [3H]- N6 -(phenylisopropyl) adenosine binding to Adenosine A1 receptor in rat fat cell membrane |
J Med Chem 32: 1231-7 (1989)
Article DOI: 10.1021/jm00126a014 BindingDB Entry DOI: 10.7270/Q2PZ57T1 |
More data for this Ligand-Target Pair | |
Adenosine A2 receptor
(Homo sapiens (Human)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
Reactome pathway
UniProtKB/SwissProt UniProtKB/TrEMBL
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| 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institutes of Health
Curated by ChEMBL
| Assay Description Inhibition of the stimulation by 5'-(N-ethylcarbamoyl) adenosine of adenyl cyclase via adenosine A2 receptor in human platelet membranes. |
J Med Chem 32: 1231-7 (1989)
Article DOI: 10.1021/jm00126a014 BindingDB Entry DOI: 10.7270/Q2PZ57T1 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
Reactome pathway KEGG
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| n/a | n/a | 1.10E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Antagonism of adenosine A1 receptor assessed from the ability to inhibit binding of [3H]-cyclohexyladenosine to rat cerebral cortical membranes |
J Med Chem 27: 1364-7 (1984)
Article DOI: 10.1021/jm00376a027 BindingDB Entry DOI: 10.7270/Q2K35SP9 |
More data for this Ligand-Target Pair | |
Adenosine A2a receptor
(GUINEA PIG) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB MMDB
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| PDB Article PubMed
| 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Compound was evaluated for its ability to antagonise cyclic [3H]-AMP accumulation in [3H]-adenine-labeled guinea pig cerebral cortical slices. |
J Med Chem 29: 1305-8 (1987)
Article DOI: 10.1021/jm00157a035 BindingDB Entry DOI: 10.7270/Q23777QX |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
Reactome pathway KEGG
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| Article PubMed
| 5.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Ability to inhibit binding of 1 nM [3H]-cyclohexyladenosine to adenosine A1 receptor in rat cerebral cortical membranes |
J Med Chem 29: 1305-8 (1987)
Article DOI: 10.1021/jm00157a035 BindingDB Entry DOI: 10.7270/Q23777QX |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
Reactome pathway KEGG
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| Article PubMed
| 4.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Julius-Maximilians-Universität Würzburg
Curated by ChEMBL
| Assay Description Ability to inhibit binding of [3H]-R-PIA to Adenosine A1 receptor in rat brain cortical membranes |
J Med Chem 40: 4396-405 (1998)
Article DOI: 10.1021/jm970515+ BindingDB Entry DOI: 10.7270/Q20K27P3 |
More data for this Ligand-Target Pair | |
Adenosine Receptors A2a (A2a)
(Rattus norvegicus (rat)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB MMDB
Reactome pathway KEGG
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| 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Julius-Maximilians-Universität Würzburg
Curated by ChEMBL
| Assay Description Ability to inhibit binding of [3H]-CGS- 21680 to adenosine A2A receptor in rat brain striatal membranes. |
J Med Chem 40: 4396-405 (1998)
Article DOI: 10.1021/jm970515+ BindingDB Entry DOI: 10.7270/Q20K27P3 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Adenosine A1 receptor
(GUINEA PIG) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
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| Article PubMed
| 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd
Curated by ChEMBL
| Assay Description Binding affinity against adenosine A1 receptor in guinea pig forebrain membranes using N6-[3H]cyclohexyladenosine as radioligand |
J Med Chem 35: 3066-75 (1992)
Article DOI: 10.1021/jm00094a022 BindingDB Entry DOI: 10.7270/Q2DN45PF |
More data for this Ligand-Target Pair | |
Adenosine A1 receptor
(GUINEA PIG) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
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| Article PubMed
| 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd
Curated by ChEMBL
| Assay Description Binding affinity against Adenosine A1 receptor from guinea pig forebrain membranes by N6-[3H]- cyclohexyladenosine displacement. |
J Med Chem 36: 2508-18 (1993)
Article DOI: 10.1021/jm00069a009 BindingDB Entry DOI: 10.7270/Q2GX4C5K |
More data for this Ligand-Target Pair | |
Adenosine A1 receptor
(BOVINE) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
Reactome pathway KEGG
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| Article PubMed
| 2.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Camerino
Curated by ChEMBL
| Assay Description Affinity to A1 adenosine receptor was measured by the displacement of [3H]-PIA in bovine brain cortical membrane |
J Med Chem 37: 2970-5 (1994)
Article DOI: 10.1021/jm00044a018 BindingDB Entry DOI: 10.7270/Q23777ST |
More data for this Ligand-Target Pair | |
Adenosine receptor A2a
(Homo sapiens (Human)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
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| 4.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Camerino
Curated by ChEMBL
| Assay Description Affinity to A2 adenosine receptor was measured by the displacement of [3H]-CGS- 21680 in bovine brain striatal membrane |
J Med Chem 37: 2970-5 (1994)
Article DOI: 10.1021/jm00044a018 BindingDB Entry DOI: 10.7270/Q23777ST |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
Reactome pathway KEGG
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| Article PubMed
| 2.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes
Curated by ChEMBL
| Assay Description Displacement of [3H]-PIA from adenosine A1 receptors of rat brain membrane |
J Med Chem 37: 3373-82 (1994)
Article DOI: 10.1021/jm00046a022 BindingDB Entry DOI: 10.7270/Q28914WW |
More data for this Ligand-Target Pair | |
Adenosine Receptors A2a (A2a)
(Rattus norvegicus (rat)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB MMDB
Reactome pathway KEGG
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| PDB Article PubMed
| 4.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes
Curated by ChEMBL
| Assay Description Displacement of [3H]-CGS- 21680 from adenosine A2a receptors of rat striatal membrane |
J Med Chem 37: 3373-82 (1994)
Article DOI: 10.1021/jm00046a022 BindingDB Entry DOI: 10.7270/Q28914WW |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Adenosine A1 receptor
(GUINEA PIG) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
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| Article PubMed
| 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd
Curated by ChEMBL
| Assay Description Binding affinity against adenosine A1 receptor using N6-[3H]cyclohexyladenosine as radioligand in guinea pig forebrain membranes |
J Med Chem 35: 924-30 (1992)
Article DOI: 10.1021/jm00083a018 BindingDB Entry DOI: 10.7270/Q2NS0VJZ |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
Reactome pathway KEGG
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| Article PubMed
| 2.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institutes of Health
Curated by ChEMBL
| Assay Description Binding affinity for adenosine A1 receptor from rat brain membranes using [3H]-PIA as radioligand |
J Med Chem 36: 2639-44 (1993)
Article DOI: 10.1021/jm00070a007 BindingDB Entry DOI: 10.7270/Q2S75FDT |
More data for this Ligand-Target Pair | |
Adenosine Receptors A2a (A2a)
(Rattus norvegicus (rat)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB MMDB
Reactome pathway KEGG
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| 2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institutes of Health
Curated by ChEMBL
| Assay Description Binding affinity for adenosine A2A receptor from rat brain membranes using [3H]-CGS-21,680 |
J Med Chem 36: 2639-44 (1993)
Article DOI: 10.1021/jm00070a007 BindingDB Entry DOI: 10.7270/Q2S75FDT |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
Reactome pathway KEGG
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| Article PubMed
| 4.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-Universität Tübingen
Curated by ChEMBL
| Assay Description Binding affinity to A1 adenosine receptor from rat cortical membrane in presence of [3H]-R-(phenylisopropyl)-adenosine |
J Med Chem 37: 1526-34 (1994)
Article DOI: 10.1021/jm00036a019 BindingDB Entry DOI: 10.7270/Q28P5ZJN |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar
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CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank Article PubMed
| 4.49E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human recombinant adenosine A1 receptor |
J Med Chem 57: 3623-50 (2014)
Article DOI: 10.1021/jm4011669 BindingDB Entry DOI: 10.7270/Q28P621J |
More data for this Ligand-Target Pair | |
Adenosine receptor A2a and A3
(Rattus norvegicus) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar
| Purchase
CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of rat recombinant adenosine A3 receptor |
J Med Chem 57: 3623-50 (2014)
Article DOI: 10.1021/jm4011669 BindingDB Entry DOI: 10.7270/Q28P621J |
More data for this Ligand-Target Pair | |
Adenosine receptor A2a
(Homo sapiens (Human)) | BDBM10849
 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar
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CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PDB Article PubMed
| 2.34E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human recombinant adenosine receptor A2a |
J Med Chem 57: 3623-50 (2014)
Article DOI: 10.1021/jm4011669 BindingDB Entry DOI: 10.7270/Q28P621J |
More data for this Ligand-Target Pair |  3D Structure (crystal) |