BDBM109863 US8609647, 1::US8609647, 15::US8609647, 2::US8609647, 23

SMILES CC1CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12

InChI Key InChIKey=YAGUGWDMCPHBFF-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 109863   

TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM109863(US8609647, 1 | US8609647, 15 | US8609647, 2 | US86...)
Affinity DataIC50:  3.40nMAssay Description:In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM109863(US8609647, 1 | US8609647, 15 | US8609647, 2 | US86...)
Affinity DataIC50:  4.70nMAssay Description:In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM109863(US8609647, 1 | US8609647, 15 | US8609647, 2 | US86...)
Affinity DataIC50:  7.10nMAssay Description:In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM109863(US8609647, 1 | US8609647, 15 | US8609647, 2 | US86...)
Affinity DataIC50:  14nMAssay Description:In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM109863(US8609647, 1 | US8609647, 15 | US8609647, 2 | US86...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full-length human Lck using TK-substrate-biotin as substrate incubated for 60 mins in presence of AT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM109863(US8609647, 1 | US8609647, 15 | US8609647, 2 | US86...)
Affinity DataIC50:  1.70nMAssay Description:In the kinase reactions, fused proteins (6His tag-fused hJAK2 kinase domain (aa808-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM109863(US8609647, 1 | US8609647, 15 | US8609647, 2 | US86...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human JAK3 (780 to end residues) expressed in baculovirus infected Sf9 cells using TK-substrate-biotin as substrate incubated for 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM109863(US8609647, 1 | US8609647, 15 | US8609647, 2 | US86...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human JAK3 (780 to end residues) expressed in baculovirus infected Sf9 cells using TK-substrate-biotin as substrate incubated for 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM109863(US8609647, 1 | US8609647, 15 | US8609647, 2 | US86...)
Affinity DataIC50:  1nMAssay Description:In the kinase reactions, fused proteins (6His tag-fused hJAK2 kinase domain (aa808-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...More data for this Ligand-Target Pair
In DepthDetails US Patent