BDBM110767 US8614206, 316::US8614206, 317::US8614206, 320::US8614206, 321

SMILES COC1CC(N)CCN(C1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnn1C

InChI Key InChIKey=XCEBXSIYXWIQPP-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 110767   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM110767(US8614206, 316 | US8614206, 317 | US8614206, 320 |...)
Affinity DataKi:  0.00700nMpH: 7.2Assay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM110767(US8614206, 316 | US8614206, 317 | US8614206, 320 |...)
Affinity DataKi:  0.0180nMpH: 7.2Assay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM110767(US8614206, 316 | US8614206, 317 | US8614206, 320 |...)
Affinity DataKi:  0.0500nMpH: 7.2Assay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM110767(US8614206, 316 | US8614206, 317 | US8614206, 320 |...)
Affinity DataKi:  0.0970nMpH: 7.2Assay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In DepthDetails US Patent