BDBM112390 US10112950, Example 86::US10556908, Example 86::US9695180, 86

SMILES CC(O)c1ccc(cc1C)-c1c(nc(OC[C@@H]2CCCN(C)C2)c2nccn12)-c1ccc(cc1)C#N

InChI Key InChIKey=YYJCEBPLOVNLOV-LWMIZPGFSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 112390   

TargetLysine-specific histone demethylase 1A [151-852](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM112390(US10112950, Example 86 | US10556908, Example 86 | ...)
Affinity DataIC50:  275nMpH: 7.5 T: 2°CAssay Description:10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM112390(US10112950, Example 86 | US10556908, Example 86 | ...)
Affinity DataIC50:  275nMAssay Description:LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM112390(US10112950, Example 86 | US10556908, Example 86 | ...)
Affinity DataIC50:  275nMpH: 7.5Assay Description:LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent