BDBM112596 US8618103, I-92

SMILES CS(=O)(=O)N1CCC[C@@H](C1)Nc1nc(NCCN)ncc1-c1cnc2[nH]ccc2n1

InChI Key InChIKey=XKLPKYDEDWXEAA-LBPRGKRZSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 112596   

TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM112596(US8618103, I-92)
Affinity DataKi:  0.0252nM IC50:  0.0504nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM112596(US8618103, I-92)
Affinity DataIC50:  0.167nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent