BDBM11350 Hydroxamate 31::N-hydroxy-2-{[(2-nitrophenyl)methyl](1,1,2,2,3,3,4,4,4-nonafluorobutane)sulfonamido}acetamide

SMILES ONC(=O)CN(Cc1ccccc1N(=O)=O)S(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F

InChI Key InChIKey=ZHENEPVPETWBJM-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 11350   

Target72 kDa type IV collagenase(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM11350(Hydroxamate 31 | N-hydroxy-2-{[(2-nitrophenyl)meth...)
Affinity DataKi:  3.70nMAssay Description:Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM11350(Hydroxamate 31 | N-hydroxy-2-{[(2-nitrophenyl)meth...)
Affinity DataKi:  4.60nMAssay Description:Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM11350(Hydroxamate 31 | N-hydroxy-2-{[(2-nitrophenyl)meth...)
Affinity DataKi:  5.5nMAssay Description:Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase ColG(Clostridium histolyticum)
Universita Degli Studi

LigandPNGBDBM11350(Hydroxamate 31 | N-hydroxy-2-{[(2-nitrophenyl)meth...)
Affinity DataKi:  13nMAssay Description:The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM11350(Hydroxamate 31 | N-hydroxy-2-{[(2-nitrophenyl)meth...)
Affinity DataKi:  25nMAssay Description:Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM11350(Hydroxamate 31 | N-hydroxy-2-{[(2-nitrophenyl)meth...)
Affinity DataKi:  100nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 4(Bos taurus (bovine))
Universita Degli Studi

LigandPNGBDBM11350(Hydroxamate 31 | N-hydroxy-2-{[(2-nitrophenyl)meth...)
Affinity DataKi:  120nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM11350(Hydroxamate 31 | N-hydroxy-2-{[(2-nitrophenyl)meth...)
Affinity DataKi: >200nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed