BDBM118214 US8673966, N-(4-(7-((1-methyl-1H-imidazol-4-yl)ethynyl)- 4-oxo-4H-chromen-3-yl)phenyl)methanesulfonamide

SMILES Cn1cnc(c1)C#Cc1ccc2c(c1)occ(-c1ccc(NS(C)(=O)=O)cc1)c2=O

InChI Key InChIKey=IOHBYWNAYAYTJD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 118214   

TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118214(US8673966, N-(4-(7-((1-methyl-1H-imidazol-4-yl)eth...)
Affinity DataIC50:  95nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118214(US8673966, N-(4-(7-((1-methyl-1H-imidazol-4-yl)eth...)
Affinity DataIC50: >1.30E+5nMpH: 7.5Assay Description:MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM118214(US8673966, N-(4-(7-((1-methyl-1H-imidazol-4-yl)eth...)
Affinity DataIC50: >8.65E+4nMpH: 7.5Assay Description:MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...More data for this Ligand-Target Pair
In DepthDetails US Patent