BDBM11834 3-{2-[(dimethylamino)methyl]-1H,2H,3H,4H-pyrido[1,2-a]indol-10-yl}-4-(1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione::BIM-11

SMILES CN(C)CC1CCn2c(C1)c(C1=C(C(=O)NC1=O)c1c[nH]c3ccccc13)c1ccccc21

InChI Key InChIKey=KAUXQCPPAWLYAB-UHFFFAOYSA-N

Data  1 Kd  1 ITC

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 11834   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Oxford University

Curated by ChEMBL
LigandPNGBDBM11834(3-{2-[(dimethylamino)methyl]-1H,2H,3H,4H-pyrido[1,...)
Affinity DataKd:  250nMAssay Description:Binding affinity to non phosphorylated PIM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 11834   

CellPNGBDBM11834(3-{2-[(dimethylamino)methyl]-1H,2H,3H,4H-pyrido[1,...)
Oxford University

SyringeSerine/threonine-protein kinase PIM(Homo sapiens (Human))
ITC DataΔG°: -8.49kcal/mole −TΔS°: -5.28kcal/mole ΔH°: -3.29kcal/mole logk: 4.00E+6
pH: 7.5 T: 10.00°C