BDBM119808 US8691852, 6

SMILES COc1cccc(c1)-c1cc(F)c(Nc2ncccc2C(O)=O)cc1F

InChI Key InChIKey=AAUOKRAJRPXVIO-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 119808   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))TBA

LigandBDBM119808(US8691852, 6)Copy SMILESCopy InChI

Affinity DataIC50:  88nMAssay Description:Inhibition of Homo sapiens (human) dehydroorotate dihydrogenase using 2,6-dichlorophenol-indophenol as substrate after 10 min by spectrophotometric a...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In DepthDetails Article
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))TBA

LigandBDBM119808(US8691852, 6)Copy SMILESCopy InChI

Affinity DataIC50:  88nMpH: 8.0Assay Description:DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichlorophenol-indophenol). The substrate oxidation (...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI