BDBM119820 US8691852, 40

SMILES CCc1cnc(Nc2c(F)cc(cc2F)-c2cccc(OC)c2)c(c1)C(O)=O

InChI Key InChIKey=CKYAQBHJTNSQAU-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 119820   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))TBA

LigandBDBM119820(US8691852, 40)Copy SMILESCopy InChI

Affinity DataIC50:  12nMAssay Description:Inhibition of Homo sapiens (human) dehydroorotate dihydrogenase using 2,6-dichlorophenol-indophenol as substrate after 10 min by spectrophotometric a...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In DepthDetails Article
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))TBA

LigandBDBM119820(US8691852, 40)Copy SMILESCopy InChI

Affinity DataIC50:  12nMpH: 8.0Assay Description:DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichlorophenol-indophenol). The substrate oxidation (...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI