BDBM120158 US8691753, 6

SMILES NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)CCc1cc(no1)-c1ccc(cc1)-c1cccc(Cl)c1

InChI Key InChIKey=KOVQMCGGWATESY-FCHUYYIVSA-N

Data  18 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 120158   

TargetMacrophage metalloelastase(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  8.30nMAssay Description:Inhibition of human MMP-12 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCollagenase 3(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  40nMAssay Description:Inhibition of human MMP-13 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetStromelysin-2(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  48nMAssay Description:Inhibition of human MMP-10 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetStromelysin-1(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  62nMAssay Description:Inhibition of human MMP-3 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins fol...More data for this Ligand-Target Pair
In DepthDetails PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  76nMAssay Description:Inhibition of human MMP-2 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins fol...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  181nMAssay Description:Inhibition of human MMP-8 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins fol...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCollagenase 3(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  235nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage metalloelastase(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  401nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target72 kDa type IV collagenase(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  403nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetStromelysin-2(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  489nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  565nMAssay Description:Inhibition of human MMP-9 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins fol...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetStromelysin-1(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi: >1.00E+3nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMatrilysin(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of human MMP-7 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins fol...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  2.06E+3nMAssay Description:Inhibition of human MMP-14 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi: >5.00E+3nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil collagenase(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi: >5.00E+3nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMatrix metalloproteinase-14 [1-20,P8S](Homo sapiens (Human))
Commissariat A L'Energie Atomique Et Aux Energies Alternatives

US Patent
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi: >1.00E+4nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  1.79E+4nMAssay Description:Inhibition of human MMP-1 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins fol...More data for this Ligand-Target Pair
In DepthDetails PubMed