BDBM12042 (2R,3R)-3-{[(1S)-1-[(4-carbamimidamidobutyl)carbamoyl]-3-methylbutyl]carbamoyl}oxirane-2-carboxylic acid::E-64::L-trans-3-Carboxyoxiran-2-carbonyl-L-leucylagmatine::N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE::trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane
SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H]-1-[#8]-[#6@H]-1-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7]
InChI Key InChIKey=LTLYEAJONXGNFG-HBNTYKKESA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 12042
Affinity DataKi: 1.40nMAssay Description:Inhibition of human cathepsin K by gelatin zymographic analysisMore data for this Ligand-Target Pair
TargetCysteine proteinase falcipain 2a(Plasmodium falciparum)
East China University Of Science And Technology
Curated by ChEMBL
East China University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 5.72E+4nMAssay Description:Inhibition of Plasmodium falciparum FP2 using Z-Leu-Arg-AMC as substrate preincubated for 30 min followed by substrate addition measured after 30 min...More data for this Ligand-Target Pair
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University Of Minas Gerais (Ufmg)
Curated by ChEMBL
Federal University Of Minas Gerais (Ufmg)
Curated by ChEMBL
Affinity DataIC50: 3.70nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesiense MVAT4 rhodesain expressed in Pichia pastoris using Z-FR-AMC as substrate by fluorometryMore data for this Ligand-Target Pair
TargetCysteine proteinase falcipain 3(Plasmodium falciparum)
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: 136nMAssay Description:Inhibition of Plasmodium falciparum N-terminal His-tagged falcipain-3 (33 residues) expressed in Escherichia coli M15 pREP4 using Z-Leu-Arg-AMC as su...More data for this Ligand-Target Pair
Affinity DataIC50: 68nMAssay Description:Inhibition of Plasmodium falciparum N-terminal His6-tagged falcipain-2 (35 residues) expressed in Escherichia coli M15 pREP4 using Z-Lue-Arg-AMC as s...More data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate by fluorometryMore data for this Ligand-Target Pair
Affinity DataIC50: 58nMpH: 5.5 T: 2°CAssay Description:The substrate peptide terminating in AMC is processed by falcipain-2 with or without inhibitors, and the accumulation of AMC was monitored in a Labsy...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Irreversible inhibition of Trypanosoma cruzi cruzipainMore data for this Ligand-Target Pair