BDBM12240 AZD0530 analogue 18::N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[(1-methylpiperidin-4-yl-)methoxy]-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine::N-(5-chloro-2H-1,3-benzodioxol-4-yl)-7-[(1-methylpiperidin-4-yl)methoxy]-5-(oxan-4-yloxy)quinazolin-4-amine

SMILES CN1CCC(COc2cc(OC3CCOCC3)c3c(Nc4c5OCOc5ccc4Cl)ncnc3c2)CC1

InChI Key InChIKey=YQPAFFIGFWEPLF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 12240   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM12240(AZD0530 analogue 18 | N-(5-Chloro-1,3-benzodioxol-...)
Affinity DataIC50:  2.00E+3nMAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM12240(AZD0530 analogue 18 | N-(5-Chloro-1,3-benzodioxol-...)
Affinity DataIC50:  6nMAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed