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BDBM123037 US8742138, 22

InChI string: InChI=1S/C19H12F3NO7/c20-19(21,22)30-10-4-1-3-9(7-10)11-5-2-6-12-14(11)15(18(28)29-17(12)27)16(26)23-8-13(24)25/h1-7,27H,8H2,(H,23,26)(H,24,25)

SMILES: OC(=O)CNC(=O)c1c2c(cccc2c(O)oc1=O)-c1cccc(OC(F)(F)F)c1

InChI Key: InChIKey=TYNGBTFQLHIIJC-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 123037   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123037
PNG
(US8742138, 22)
Show SMILES OC(=O)CNC(=O)c1c2c(cccc2c(O)oc1=O)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C19H12F3NO7/c20-19(21,22)30-10-4-1-3-9(7-10)11-5-2-6-12-14(11)15(18(28)29-17(12)27)16(26)23-8-13(24)25/h1-7,27H,8H2,(H,23,26)(H,24,25)
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MMDB

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US Patent
n/an/a 100n/an/an/an/an/an/a



Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


Citation and Details
More data for this
Ligand-Target Pair