BDBM123754 1-methyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (13)

SMILES Cn1nc(-c2cccc3ccccc23)c2c(N)ncnc12

InChI Key InChIKey=HTNPEYORVSYSHK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 123754   

TargetPhospholipase D1(Homo sapiens (Human))
University Of Massachusetts Boston

LigandPNGBDBM123754(1-methyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyr...)
Affinity DataIC50:  20nMT: 2°CAssay Description:PLD enzymes (50 nM) were reconstituted with phospholipid vesicle substrates. All assays were performed at 37 C with agitation for 30 min. Reactions...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase D(Streptomyces chromofuscus)
Roxbury Community College

LigandPNGBDBM123754(1-methyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyr...)
Affinity DataIC50:  20nMpH: 8.0Assay Description:A NaOH stock solution (50 mM) was standardized with KHP then diluted in Millipore water (10-fold serial dilutions) then used to hold the pH constant ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase D(Streptomyces sp. PMF)
University Of Massachusetts Boston

LigandPNGBDBM123754(1-methyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyr...)
Affinity DataIC50:  800nMT: 2°CAssay Description:PLD enzymes (50 nM) were reconstituted with phospholipid vesicle substrates. All assays were performed at 37 C with agitation for 30 min. Reactions...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase D2(Homo sapiens (Human))
University Of Massachusetts Boston

LigandPNGBDBM123754(1-methyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyr...)
Affinity DataIC50:  2.30E+3nMT: 2°CAssay Description:PLD enzymes (50 nM) were reconstituted with phospholipid vesicle substrates. All assays were performed at 37 C with agitation for 30 min. Reactions...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed