BDBM12579 (1-hydroxy-2-phenyl-1-phosphonoethyl)phosphonic acid::Bisphosphonate 4::CHEMBL56556
SMILES OC(Cc1ccccc1)(P(O)(O)=O)P(O)(O)=O
InChI Key InChIKey=DNTYYKAZXNGNBX-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 12579
Affinity DataKi: 303nMAssay Description:Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 minsMore data for this Ligand-Target Pair
Affinity DataKi: 368nMAssay Description:Inhibition of human recombinant FPPS expressed in Escherichia coli BL21More data for this Ligand-Target Pair
Affinity DataKi: 1.60E+3nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80E+4nMAssay Description:Concentration required for 50% inhibition of Inositol monophosphataseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.66E+4nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME? (M)More data for this Ligand-Target Pair
Affinity DataIC50: 1.63E+3nMAssay Description:Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human recombinant FPPS expressed in Escherichia coli BL21More data for this Ligand-Target Pair
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign
Curated by ChEMBL
University Of Illinois At Urbana-Champaign
Curated by ChEMBL
Affinity DataIC50: 2.20E+5nMAssay Description:Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase).More data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 2 hits for monomerid = 12579
CellFarnesyl Diphosphate Synthase (FPPS)(Trypanosoma brucei)
University Of Illinois At Urbana-Champaign
University Of Illinois At Urbana-Champaign
ITC DataΔG°: -7.45kcal/mole −TΔS°: 2.53kcal/mole ΔH°: -9.96kcal/mole logk: 3.13E+5
pH: 7.4 T: 26.85°C
pH: 7.4 T: 26.85°C
CellFarnesyl Diphosphate Synthase (FPPS)(Trypanosoma brucei)
University Of Illinois At Urbana-Champaign
University Of Illinois At Urbana-Champaign
ITC DataΔG°: -7.47kcal/mole −TΔS°: 2.77kcal/mole ΔH°: -10.2kcal/mole logk: 3.20E+5
pH: 8.5 T: 26.85°C
pH: 8.5 T: 26.85°C