BDBM125902 US8765727, 5

SMILES Clc1cnc2Nc3cccc(CCCOc4cccc(CNc1n2)c4)c3

InChI Key InChIKey=WILMKMPUMOSDLH-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 125902   

TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM125902(US8765727, 5)
Affinity DataIC50:  706nMpH: 7.8Assay Description:HTRF kinase assay: 40 μL reactions were run in black 384 well polystyrene plates in assay buffer (50 mM Tris, pH 7.8, 100 mM NaCI, 0.1 mg/mL BSA...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM125902(US8765727, 5)
Affinity DataIC50:  4.20nMpH: 7.8 T: 2°CAssay Description:One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM125902(US8765727, 5)
Affinity DataIC50:  25nMAssay Description:TYK2 assays described by James E. Thompson et. al, Photochemical preparation of a pyridone containing tetracycle: A JAK protein kinase inhibitor, Bio...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM125902(US8765727, 5)
Affinity DataIC50:  2.40nMpH: 7.8 T: 2°CAssay Description:One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM125902(US8765727, 5)
Affinity DataIC50:  1.90nMpH: 7.8 T: 2°CAssay Description:One or more compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., A...More data for this Ligand-Target Pair
In DepthDetails US Patent