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BDBM126811 US8785489, 4-{[({4-[1-(4-fluoro-3-methylbenzyl)-1H-pyrazol-4-yl]pyridin-2-yl}carbonyl)amino]methyl}benzoic acid

SMILES: Cc1cc(Cn2cc(cn2)-c2ccnc(c2)C(=O)NCc2ccc(cc2)C(O)=O)ccc1F

InChI Key: InChIKey=ZLTDLBRBOOFDIE-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 126811   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Matrix metallopeptidase 13 (MMP13)


(Mus musculus (Mouse))
BDBM126811
PNG
(US8785489, 4-{[({4-[1-(4-fluoro-3-methylbenzyl)-1H...)
Show SMILES Cc1cc(Cn2cc(cn2)-c2ccnc(c2)C(=O)NCc2ccc(cc2)C(O)=O)ccc1F
Show InChI InChI=1S/C25H21FN4O3/c1-16-10-18(4-7-22(16)26)14-30-15-21(13-29-30)20-8-9-27-23(11-20)24(31)28-12-17-2-5-19(6-3-17)25(32)33/h2-11,13,15H,12,14H2,1H3,(H,28,31)(H,32,33)
PDB
MMDB

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PC cid
PC sid
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US Patent
n/an/a 130n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...


US Patent US8785489 (2014)


BindingDB Entry DOI: 10.7270/Q24B300F
More data for this
Ligand-Target Pair