BDBM12686 1-(3-amino-1,2-benzoxazol-5-yl)-7-(4-{2-[(dimethylamino)methyl]phenyl}-2-fluorophenyl)-3-(trifluoromethyl)-1H,6H,7H,8H-pyrazolo[3,4-c]azepin-8-one::BMS-740808 Analogue 17b::bicyclic pyrazole scaffold

SMILES CN(C)Cc1ccccc1-c1ccc(N2CC=Cc3c(nn(c3C2=O)-c2ccc3onc(N)c3c2)C(F)(F)F)c(F)c1

InChI Key InChIKey=MZRBGTNVLDWXCY-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 12686   

TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM12686(1-(3-amino-1,2-benzoxazol-5-yl)-7-(4-{2-[(dimethyl...)
Affinity DataKi:  0.600nM ΔG°:  -12.4kcal/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed