BDBM127399 US8791131, 163

SMILES COc1ncc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC(=O)N(C)C)CC4)c3c2n1

InChI Key InChIKey=VMQKJOBTEJANRR-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 127399   

LigandPNGBDBM127399(US8791131, 163)
Affinity DataKi:  4.70nM ΔG°:  -11.4kcal/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM127399(US8791131, 163)
Affinity DataKi:  18.4nM ΔG°:  -10.5kcal/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In DepthDetails US Patent