BDBM127422 US8791131, 196
SMILES CNC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2ccc(nc2)N(C)C)n(C)c1=O
InChI Key InChIKey=GEFIJVBUAHDDEM-UHFFFAOYSA-N
Data 2 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 127422
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer
US Patent
Pfizer
US Patent
Affinity DataKi: 0.760nM ΔG°: -12.4kcal/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
Affinity DataKi: 3.01nM ΔG°: -11.6kcal/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair