BDBM128409 US8802695, 25

SMILES Cn1c(Cl)c(Cl)c2cnc(NC(=O)c3ccc(cc3)C(C)(C)O)cc12

InChI Key InChIKey=JYCUSHKOWZOHEL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 128409   

TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM128409(US8802695, 25)
Affinity DataIC50:  146nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM128409(US8802695, 25)
Affinity DataIC50:  60nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
In DepthDetails US Patent