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BDBM13271 BMS-354825 2-Heteroarylamino-thiazole Analog 12p::N-(2-Chloro-6-methylphenyl)-2-(6-(2-hydroxyethylamino)pyridin-2-ylamino)-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-({6-[(2-hydroxyethyl)amino]pyridin-2-yl}amino)-1,3-thiazole-5-carboxamide

SMILES: Cc1cccc(Cl)c1NC(=O)c1cnc(Nc2cccc(NCCO)n2)s1

InChI Key: InChIKey=HLEQFFPIXAPVEP-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 13271   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
SRC


(Homo sapiens (human))
BDBM13271
PNG
(BMS-354825 2-Heteroarylamino-thiazole Analog 12p |...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(Nc2cccc(NCCO)n2)s1
Show InChI InChI=1S/C18H18ClN5O2S/c1-11-4-2-5-12(19)16(11)24-17(26)13-10-21-18(27-13)23-15-7-3-6-14(22-15)20-8-9-25/h2-7,10,25H,8-9H2,1H3,(H,24,26)(H2,20,21,22,23)
PDB
MMDB

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UniProtKB/SwissProt

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Patents


Similars

Article
PubMed
n/an/a<0.200n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair