BDBM133673 US8846711, 17::US9051321, 17
SMILES O=C(\C=C\c1cnc2NC(=O)CCc2c1)N1CC(C1)OCc1ccccc1
InChI Key InChIKey=HNGPQMJMLWSXHM-RMKNXTFCSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 133673
Affinity DataIC50: 50nMpH: 6.5 T: 2°CAssay Description:Compound inhibitory activity of FabI enzyme is measured in vitro by the IC5 so determination using a fluorescence based assay.The protein FabI from S...More data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI [9-251](Staphylococcus aureus)
Aurigene Discovery Technologies
Curated by ChEMBL
Aurigene Discovery Technologies
Curated by ChEMBL
Affinity DataIC50: 376nMAssay Description:Inhibition of Staphylococcus aureus FabI-mediated reduction of enoyl-ACP preincubated for 30 mins measured after 2 hrs by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMpH: 6.5 T: 2°CAssay Description:The assay buffer "AB" contained 50 mM ADA (N-(2-acetamido)iminodiacetic acid monosodium salt) pH 6.5, 1 mM dithiothreitol, 0.006% Triton-X100 and 50 ...More data for this Ligand-Target Pair