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BDBM135765 US8846601, 150::US9458201, 150

SMILES: CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O

InChI Key: InChIKey=SUYDUGVDUFCDHQ-IQSCWYJSSA-N

Data: 4 KI  2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 135765   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135765
PNG
(US8846601, 150 | US9458201, 150)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(14-8-22-57-48(52)53)42(71)62-34-15-7-21-56-40(69)20-18-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-44(73)35(16-9-23-58-49(54)55)63-46(75)37(24-28-10-3-2-4-11-28)65-45(74)36(64-43(34)72)17-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,71)(H,63,75)(H,64,72)(H,65,74)(H,66,73)(H4,52,53,57)(H4,54,55,58)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem

Similars

5n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135765
PNG
(US8846601, 150 | US9458201, 150)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(14-8-22-57-48(52)53)42(71)62-34-15-7-21-56-40(69)20-18-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-44(73)35(16-9-23-58-49(54)55)63-46(75)37(24-28-10-3-2-4-11-28)65-45(74)36(64-43(34)72)17-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,71)(H,63,75)(H,64,72)(H,65,74)(H,66,73)(H4,52,53,57)(H4,54,55,58)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

5 -11.8n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135765
PNG
(US8846601, 150 | US9458201, 150)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(14-8-22-57-48(52)53)42(71)62-34-15-7-21-56-40(69)20-18-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-44(73)35(16-9-23-58-49(54)55)63-46(75)37(24-28-10-3-2-4-11-28)65-45(74)36(64-43(34)72)17-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,71)(H,63,75)(H,64,72)(H,65,74)(H,66,73)(H4,52,53,57)(H4,54,55,58)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

130 -9.77n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135765
PNG
(US8846601, 150 | US9458201, 150)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(14-8-22-57-48(52)53)42(71)62-34-15-7-21-56-40(69)20-18-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-44(73)35(16-9-23-58-49(54)55)63-46(75)37(24-28-10-3-2-4-11-28)65-45(74)36(64-43(34)72)17-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,71)(H,63,75)(H,64,72)(H,65,74)(H,66,73)(H4,52,53,57)(H4,54,55,58)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

130n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135765
PNG
(US8846601, 150 | US9458201, 150)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(14-8-22-57-48(52)53)42(71)62-34-15-7-21-56-40(69)20-18-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-44(73)35(16-9-23-58-49(54)55)63-46(75)37(24-28-10-3-2-4-11-28)65-45(74)36(64-43(34)72)17-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,71)(H,63,75)(H,64,72)(H,65,74)(H,66,73)(H4,52,53,57)(H4,54,55,58)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/an/an/a 9n/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135765
PNG
(US8846601, 150 | US9458201, 150)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(14-8-22-57-48(52)53)42(71)62-34-15-7-21-56-40(69)20-18-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-44(73)35(16-9-23-58-49(54)55)63-46(75)37(24-28-10-3-2-4-11-28)65-45(74)36(64-43(34)72)17-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,71)(H,63,75)(H,64,72)(H,65,74)(H,66,73)(H4,52,53,57)(H4,54,55,58)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/an/an/a 0.300n/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair