BDBM136078 US8853203, 104::US9650377, Example 104

SMILES O=C1CN=C(C=C2N1CCc1c(cccc21)-c1ncco1)n1cnc(c1)C1CC1

InChI Key InChIKey=XRFYMVPMURJIHU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 136078   

TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM136078(US8853203, 104 | US9650377, Example 104)
Affinity DataIC50:  7nMAssay Description:Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM136078(US8853203, 104 | US9650377, Example 104)
Affinity DataIC50:  1.30E+3nMAssay Description:Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM136078(US8853203, 104 | US9650377, Example 104)
Affinity DataIC50:  7nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM136078(US8853203, 104 | US9650377, Example 104)
Affinity DataIC50:  1.30E+3nMAssay Description:Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc...More data for this Ligand-Target Pair
In DepthDetails US Patent