BDBM138365 US10278929, Compound 14::US11337935, Compound 14::US8877795, 14

SMILES CN1C(=N)NC(=O)\C1=C\c1cc(Br)c(O)c(Br)c1

InChI Key InChIKey=XBSUMZSVMPLGBU-YWEYNIOJSA-N

Data  3 IC50  1 Kd  1 ITC

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 138365   

TargetTransthyretin(Homo sapiens (Human))
The Board Of Trustees Of The Leland Stanford Junior University

US Patent
LigandPNGBDBM138365(US10278929, Compound 14 | US11337935, Compound 14 ...)
Affinity DataIC50:  1.15E+3nMAssay Description:The FP assay was then adapted for HTS and used to screen ~120,000 small molecule library for compounds that displaced probe 5 from the T4 binding of ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransthyretin(Homo sapiens (Human))
The Board Of Trustees Of The Leland Stanford Junior University

US Patent
LigandPNGBDBM138365(US10278929, Compound 14 | US11337935, Compound 14 ...)
Affinity DataIC50:  1.15E+3nMAssay Description:Table 3: The FP assay was then adapted for HTS and used to screen 120,000 small molecule library for compounds that displaced probe 5 from the T4 bin...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransthyretin(Homo sapiens (Human))
The Board Of Trustees Of The Leland Stanford Junior University

US Patent
LigandPNGBDBM138365(US10278929, Compound 14 | US11337935, Compound 14 ...)
Affinity DataKd:  245nMAssay Description:Dissociation Constants (Kd) associated with the binding of ligands to TTR are expressed in nM. Thermodynamic Binding Parameters associated with ligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransthyretin(Homo sapiens (Human))
The Board Of Trustees Of The Leland Stanford Junior University

US Patent
LigandPNGBDBM138365(US10278929, Compound 14 | US11337935, Compound 14 ...)
Affinity DataIC50:  1.15E+3nMAssay Description:The FP assay was then adapted for HTS and used to screen a ˜120,000 member small molecule library for compounds that displaced the FP probe from the ...More data for this Ligand-Target Pair
In DepthDetails US Patent

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 138365   

CellTransthyretin(Homo sapiens (Human))
Leland Stanford Junior University

US Patent
SyringePNGBDBM138365(US10278929, Compound 14 | US11337935, Compound 14 ...)
ITC DataΔG°: -9.03kcal/mole −TΔS°: -2.36kcal/mole ΔH°: -6.66kcal/mole logk: 4.19E+6
pH: 7.5 T: 25.00°C 
In DepthDetails US Patent