BDBM13909 CHEMBL438805::ethyl 4-[(1-benzyl-1H-indazol-5-yl)amino]-5-propylpyrrolo[1,2-a][1,2,4]triazine-6-carboxylate::pyrrolo[2,1-f][1,2,4]triazine analog 5j

SMILES CCCc1c(cn2ncnc(Nc3ccc4n(Cc5ccccc5)ncc4c3)c12)C(=O)OCC

InChI Key InChIKey=VRGOWRHHJHLAFC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 13909   

TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13909(CHEMBL438805 | ethyl 4-[(1-benzyl-1H-indazol-5-yl)...)
Affinity DataIC50:  1.20E+3nMAssay Description:The kinase activity was determined by using recombinant enzyme incubating with its substrate in the presence of test compound and ATP/[gamma-33P] ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13909(CHEMBL438805 | ethyl 4-[(1-benzyl-1H-indazol-5-yl)...)
Affinity DataIC50:  1.20E+3nMAssay Description:In vitro inhibitory concentration against HER2 cytoplasmic sequence expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13909(CHEMBL438805 | ethyl 4-[(1-benzyl-1H-indazol-5-yl)...)
Affinity DataIC50:  950nMAssay Description:In vitro inhibitory concentration against EGFR cytoplasmic sequence expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13909(CHEMBL438805 | ethyl 4-[(1-benzyl-1H-indazol-5-yl)...)
Affinity DataIC50:  950nMAssay Description:The kinase activity was determined by using recombinant enzyme incubating with its substrate in the presence of test compound and ATP/[gamma-33P] ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed