BindingDB logo
myBDB logout

BDBM141376 US8916600, 10

SMILES: C[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1cccc(c1)C(=O)N[C@@H]1CCC[C@@H]1O)c1ccc2OCCOc2c1

InChI Key: InChIKey=SFWUZQCSQUYBEM-WPQAOXEXSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 141376   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM141376
PNG
(US8916600, 10)
Show SMILES C[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1cccc(c1)C(=O)N[C@@H]1CCC[C@@H]1O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C33H34F2N4O6/c1-19(37-32(42)33(2,34)35)30(20-9-12-28-29(17-20)44-14-13-43-28)45-24-10-11-26-22(16-24)18-36-39(26)23-6-3-5-21(15-23)31(41)38-25-7-4-8-27(25)40/h3,5-6,9-12,15-19,25,27,30,40H,4,7-8,13-14H2,1-2H3,(H,37,42)(H,38,41)/t19-,25+,27-,30-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/a 0.647n/an/an/an/a7.425



Astrazeneca AB; Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 uM. ...


US Patent US8916600 (2014)


BindingDB Entry DOI: 10.7270/Q2WQ02HG
More data for this
Ligand-Target Pair