BDBM141378 US8916600, 12::US9738632, Example 12

SMILES C[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1cccc(c1)C(=O)NCc1cccnc1)c1ccc2OCCOc2c1

InChI Key InChIKey=WNNXPJZAYDDMCY-BGOLNKOXSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 141378   

TargetGlucocorticoid receptor(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM141378(US8916600, 12 | US9738632, Example 12)
Affinity DataIC50:  0.767nMpH: 7.4 T: 2°CAssay Description:In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 uM. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucocorticoid receptor(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM141378(US8916600, 12 | US9738632, Example 12)
Affinity DataIC50:  0.767nMAssay Description:In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMineralocorticoid receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM141378(US8916600, 12 | US9738632, Example 12)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]-aldosterone from N terminal maltose binding protein tagged human mineralocorticoid receptor LBD (726 to 984 residues) expressed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM141378(US8916600, 12 | US9738632, Example 12)
Affinity DataIC50:  8.28E+3nMAssay Description:Displacement of fluormone labelled PL Red from human recombinant progesterone receptor after 1 to 6 hrs ligand by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM141378(US8916600, 12 | US9738632, Example 12)
Affinity DataIC50:  0.170nMAssay Description:Transrepression of glucocorticoid receptor in human PBMC assessed as inhibition of LPS induced TNF alpha release preincubated for 45 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM141378(US8916600, 12 | US9738632, Example 12)
Affinity DataIC50:  0.0370nMAssay Description:Displacement of fluormone labelled GS Red from human recombinant glucocorticoid receptor after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM141378(US8916600, 12 | US9738632, Example 12)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of fluormone labelled EL Red from human recombinant estrogen receptor alpha after 1 to 5 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM141378(US8916600, 12 | US9738632, Example 12)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of fluormone labelled EL Red from human recombinant estrogen receptor beta after 1 to 5 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(RAT)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM141378(US8916600, 12 | US9738632, Example 12)
Affinity DataIC50:  0.290nMAssay Description:Transrepression of glucocorticoid receptor in Wistar rat PBMC assessed as inhibition of LPS induced TNF alpha release preincubated for 45 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM141378(US8916600, 12 | US9738632, Example 12)
Affinity DataIC50:  1nMAssay Description:Displacement of fluormone labelled GS Red from human recombinant glucocorticoid receptor after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Rattus norvegicus (Rat))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM141378(US8916600, 12 | US9738632, Example 12)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of fluormone labelled AL green from rat recombinant His/GST-tagged androgen receptor LBD after 4 to 6 hrs by fluorescence polarization a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed