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BDBM141384 US8916600, 18

SMILES: C[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1cccc(c1)C(=O)N[C@H]1CCC[C@@H]1O)c1ccc2COCOc2c1

InChI Key: InChIKey=AGELDMBCFGFBAP-IISQNECDSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 141384   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM141384
PNG
(US8916600, 18)
Show SMILES C[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1cccc(c1)C(=O)N[C@H]1CCC[C@@H]1O)c1ccc2COCOc2c1
Show InChI InChI=1S/C33H34F2N4O6/c1-19(37-32(42)33(2,34)35)30(20-9-10-22-17-43-18-44-29(22)15-20)45-25-11-12-27-23(14-25)16-36-39(27)24-6-3-5-21(13-24)31(41)38-26-7-4-8-28(26)40/h3,5-6,9-16,19,26,28,30,40H,4,7-8,17-18H2,1-2H3,(H,37,42)(H,38,41)/t19-,26-,28-,30-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/a 3.44n/an/an/an/a7.425



Astrazeneca AB; Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 uM. ...


US Patent US8916600 (2014)


BindingDB Entry DOI: 10.7270/Q2WQ02HG
More data for this
Ligand-Target Pair