BDBM142741 US8937095, 3

SMILES FC(F)CNC(=O)C#Cc1ccc2\C(=C(\Nc3ccc(CN4CCCC4)cc3)c3ccccc3)C(=O)Nc2c1

InChI Key InChIKey=HIHSPODSHWNEQD-FLWNBWAVSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 142741   

TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM142741(US8937095, 3)
Affinity DataIC50:  3nMpH: 7.6Assay Description:The ATP-KM value of the complex is 61 uM. The kinase assays are run in the presence of 100 uM ATP using 10 uM of a substrate peptide. pAUB-IN847 was ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B-B(Xenopus laevis (African clawed frog))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM142741(US8937095, 3)
Affinity DataIC50:  4nMpH: 7.6Assay Description:The ATP-KM value of the complex is 61 uM. The kinase assays are run in the presence of 100 uM ATP using 10 uM of a substrate peptide. pAUB-IN847 was ...More data for this Ligand-Target Pair
In DepthDetails US Patent