BDBM143461 US8969341, 102

SMILES COc1ccc(cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C)C(=O)NCCN1CCCC1

InChI Key InChIKey=YVYATCZGDDDVSH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 143461   

TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM143461(US8969341, 102)
Affinity DataIC50:  1.80nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM143461(US8969341, 102)
Affinity DataIC50:  0.238nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtein Mdm4(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM143461(US8969341, 102)
Affinity DataIC50:  193nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In DepthDetails US Patent