BDBM14369 3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(4-methyl-benzyloxy)-1-methyl-ethyl]-3H-purin-6-ylamine::3-{[3-(cyclopentyloxy)-4-methoxyphenyl]methyl}-8-{2-[(4-methylphenyl)methoxy]propan-2-yl}-3H-purin-6-amine::V11294 Analogue 5e

SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)OCc2ccc(C)cc2)cc1OC1CCCC1

InChI Key InChIKey=TYNNSCONBDUZBR-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 14369   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Purdue Pharma

LigandPNGBDBM14369(3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(4-meth...)
Affinity DataKi:  6.60nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Purdue Pharma

LigandPNGBDBM14369(3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(4-meth...)
Affinity DataKi:  7.60nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Purdue Pharma

LigandPNGBDBM14369(3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(4-meth...)
Affinity DataKi:  9.80nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Purdue Pharma

LigandPNGBDBM14369(3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(4-meth...)
Affinity DataKi:  206nM ΔG°:  -9.02kcal/molepH: 8.0 T: 2°CAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Purdue Pharma

LigandPNGBDBM14369(3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(4-meth...)
Affinity DataKi:  347nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed