BDBM14465 (+)-4-(3-Bromo-8-chloro-10-fluoro-6,11-dihydro-5H-benzo-[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-4-(4-pyridinylacetyl)-piperazine N4-Oxide::4-(2-{4-[(2R)-6-bromo-13-chloro-15-fluoro-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-2-yl]piperazin-1-yl}-2-oxoethyl)-1-oxidopyridin-1-ium::Trihalobenzocycloheptapyridine Tricyclic Compound 37

SMILES [O-][n+]1ccc(CC(=O)N2CCN(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(F)c23)cc1

InChI Key InChIKey=JOCGRWHRWNIISC-RUZDIDTESA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 14465   

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM14465((+)-4-(3-Bromo-8-chloro-10-fluoro-6,11-dihydro-5H-...)
Affinity DataIC50:  16.7nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed