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BDBM145263 US8952169, 114::US8952169, 42

SMILES: CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CCCCCC2)cc1F

InChI Key: InChIKey=ZMZMTLVOKPHHDL-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 145263   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145263
PNG
(US8952169, 114 | US8952169, 42)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CCCCCC2)cc1F
Show InChI InChI=1S/C16H21ClFNO4S/c1-24(21,22)19-16(20)12-8-13(17)15(9-14(12)18)23-10-11-6-4-2-3-5-7-11/h8-9,11H,2-7,10H2,1H3,(H,19,20)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 44n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145263
PNG
(US8952169, 114 | US8952169, 42)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CCCCCC2)cc1F
Show InChI InChI=1S/C16H21ClFNO4S/c1-24(21,22)19-16(20)12-8-13(17)15(9-14(12)18)23-10-11-6-4-2-3-5-7-11/h8-9,11H,2-7,10H2,1H3,(H,19,20)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 44n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair