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BDBM145314 US8952169, 93

SMILES: CS(=O)(=O)NC(=O)c1cc(Cl)c(OC[C@H]2CC[C@H](CC2)C(F)(F)F)cc1F

InChI Key: InChIKey=PNBGEHIKRCJVCN-AOOOYVTPSA-N

Data: 1 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 145314   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145314
PNG
(US8952169, 93)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OC[C@H]2CC[C@H](CC2)C(F)(F)F)cc1F
Show InChI InChI=1S/C16H18ClF4NO4S/c1-27(24,25)22-15(23)11-6-12(17)14(7-13(11)18)26-8-9-2-4-10(5-3-9)16(19,20)21/h6-7,9-10H,2-5,8H2,1H3,(H,22,23)/t9-,10+
PDB

KEGG

UniProtKB/SwissProt

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DrugBank
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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 86n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair