BindingDB logo
myBDB logout

BDBM145519 US8952169, 315

SMILES: Fc1cc(OCC2CCC3(CC3)CC2)c(Cl)cc1C(=O)NS(=O)(=O)C1CC1

InChI Key: InChIKey=GGNDMXHPIAAKFM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 145519   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145519
PNG
(US8952169, 315)
Show SMILES Fc1cc(OCC2CCC3(CC3)CC2)c(Cl)cc1C(=O)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C19H23ClFNO4S/c20-15-9-14(18(23)22-27(24,25)13-1-2-13)16(21)10-17(15)26-11-12-3-5-19(6-4-12)7-8-19/h9-10,12-13H,1-8,11H2,(H,22,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/a 19n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145519
PNG
(US8952169, 315)
Show SMILES Fc1cc(OCC2CCC3(CC3)CC2)c(Cl)cc1C(=O)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C19H23ClFNO4S/c20-15-9-14(18(23)22-27(24,25)13-1-2-13)16(21)10-17(15)26-11-12-3-5-19(6-4-12)7-8-19/h9-10,12-13H,1-8,11H2,(H,22,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/a 19n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair