BDBM145743 US8952177, 97::US9089569, 97::US9695149, 97

SMILES Cc1ccc(Cn2c(nc3c(F)cc(OCc4ccn(C)n4)cc23)[C@@H]2CCCC[C@@H]2C(O)=O)cc1

InChI Key InChIKey=SGBGROQTUQNBGD-YADHBBJMSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 145743   

TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM145743(US8952177, 97 | US9089569, 97 | US9695149, 97)
Affinity DataKi:  7.5nMAssay Description:FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM145743(US8952177, 97 | US9089569, 97 | US9695149, 97)
Affinity DataKi:  7.5nMAssay Description:The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM145743(US8952177, 97 | US9089569, 97 | US9695149, 97)
Affinity DataKi:  7.5nMAssay Description:The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...More data for this Ligand-Target Pair
In DepthDetails US Patent