BDBM146692 US8957073, 4.26::US9718803, 4.26

SMILES CCOc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1

InChI Key InChIKey=FBKDIEYISUEUCG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 146692   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM146692(US8957073, 4.26 | US9718803, 4.26)
Affinity DataIC50:  0.0110nMT: 2°CAssay Description:An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM146692(US8957073, 4.26 | US9718803, 4.26)
Affinity DataIC50:  0.0106nMT: 2°CAssay Description:Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...More data for this Ligand-Target Pair
In DepthDetails US Patent