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BDBM146890 US8957073, 24.3::US9718803, 24.3

SMILES: NC(=O)C1CCN(CC1)c1nccnc1C1CN(C1)c1ccc2ccccc2n1

InChI Key: InChIKey=RDISXHYFVLOZDN-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 146890   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146890
PNG
(US8957073, 24.3 | US9718803, 24.3)
Show SMILES NC(=O)C1CCN(CC1)c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H24N6O/c23-21(29)16-7-11-27(12-8-16)22-20(24-9-10-25-22)17-13-28(14-17)19-6-5-15-3-1-2-4-18(15)26-19/h1-6,9-10,16-17H,7-8,11-14H2,(H2,23,29)
PDB
MMDB

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UniProtKB/SwissProt

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DrugBank
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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.480n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146890
PNG
(US8957073, 24.3 | US9718803, 24.3)
Show SMILES NC(=O)C1CCN(CC1)c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H24N6O/c23-21(29)16-7-11-27(12-8-16)22-20(24-9-10-25-22)17-13-28(14-17)19-6-5-15-3-1-2-4-18(15)26-19/h1-6,9-10,16-17H,7-8,11-14H2,(H2,23,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.480n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair