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BDBM14771 (E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylidene}amino carbamate::Filaminast::[1-(3-cyclopentyloxy-4-methoxy-phenyl)ethylideneamino] carbamate

SMILES: COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O

InChI Key: InChIKey=STTRYQAGHGJXJJ-UHFFFAOYSA-N

Data: 12 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 14771   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 1


(Homo sapiens (human))
BDBM14771
PNG
((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O
Show InChI InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)
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n/an/a 1.90E+5n/an/an/an/a7.530



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Structure 12: 2233-47 (2004)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 2 (PDE2A)


(Homo sapiens (human))
BDBM14771
PNG
((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O
Show InChI InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)
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n/an/a 8.90E+4n/an/an/an/a7.530



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Structure 12: 2233-47 (2004)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B)


(Homo sapiens (human))
BDBM14771
PNG
((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O
Show InChI InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)
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n/an/a 9.40E+3n/an/an/an/an/an/a



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Structure 12: 2233-47 (2004)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 4 (PDE4B)


(Homo sapiens (human))
BDBM14771
PNG
((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O
Show InChI InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)
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n/an/a 960n/an/an/an/an/an/a



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Structure 12: 2233-47 (2004)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphodiesterase Type 4 (PDE4D)


(Homo sapiens (human))
BDBM14771
PNG
((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O
Show InChI InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Structure 12: 2233-47 (2004)

More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens (human))
BDBM14771
PNG
((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O
Show InChI InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)
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n/an/a 960n/an/an/an/an/an/a



King's College London

Curated by ChEMBL


Assay Description
Inhibition of human MAPK p38alpha


Bioorg Med Chem 18: 2204-18 (2010)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 7 (PDE7B)


(Homo sapiens (human))
BDBM14771
PNG
((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O
Show InChI InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)
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n/an/a 990n/an/an/an/an/an/a



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Structure 12: 2233-47 (2004)

More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM14771
PNG
((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O
Show InChI InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)
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n/an/a 1.20E+5n/an/an/an/an/an/a



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Structure 12: 2233-47 (2004)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 9 (PDE9A)


(Homo sapiens (human))
BDBM14771
PNG
((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O
Show InChI InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)
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n/an/a>2.00E+5n/an/an/an/an/an/a



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Structure 12: 2233-47 (2004)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Homo sapiens (human))
BDBM14771
PNG
((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O
Show InChI InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)
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n/an/a 2.70E+4n/an/an/an/an/an/a



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Structure 12: 2233-47 (2004)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 11 (PDE11A)


(Homo sapiens (human))
BDBM14771
PNG
((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O
Show InChI InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)
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n/an/a 5.70E+4n/an/an/an/an/an/a



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Structure 12: 2233-47 (2004)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 5 (PDE5A)


(Homo sapiens (human))
BDBM14771
PNG
((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(C)=NOC(N)=O
Show InChI InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)
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n/an/a 5.30E+4n/an/an/an/an/an/a



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Structure 12: 2233-47 (2004)

More data for this
Ligand-Target Pair