BDBM14957 5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(2-((3-(dimethylamino)propyl)(methyl)amino)-5-(trifluoromethyl)phenyl)-2-fluorobenzamide::5-[2-(2-aminopyrimidin-5-yl)ethynyl]-N-(2-{[3-(dimethylamino)propyl](methyl)amino}-5-(trifluoromethyl)phenyl)-2-fluorobenzamide::alkynylpyrimidine amide 6h

SMILES CN(C)CCCN(C)c1ccc(cc1NC(=O)c1cc(ccc1F)C#Cc1cnc(N)nc1)C(F)(F)F

InChI Key InChIKey=CPTZKLNMWGFJMW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 14957   

TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM14957(5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(2-((3-(dim...)
Affinity DataIC50:  8nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck [245-498](Homo sapiens (Human))
Amgen

LigandPNGBDBM14957(5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(2-((3-(dim...)
Affinity DataIC50:  21nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM14957(5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(2-((3-(dim...)
Affinity DataIC50:  11nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed