BDBM150062 US8975417, 122
SMILES Cc1nn(C2CC2)c2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2n1
InChI Key InChIKey=ZHPOSNUANCLXCO-LJQANCHMSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 150062
Affinity DataIC50: <11nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Affinity DataIC50: >3.70E+4nMpH: 7.5 T: 2°CAssay Description:In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of His-tagged CREBP (unknown origin) using acetyl-histone H4 as substrate after 35 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Texas Medical Branch
Curated by ChEMBL
University Of Texas Medical Branch
Curated by ChEMBL
Affinity DataIC50: <11nMAssay Description:Inhibition of His-tagged BRD4 (unknown origin) using acetyl-histone H4 as substrate after 35 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Texas Medical Branch
Curated by ChEMBL
University Of Texas Medical Branch
Curated by ChEMBL
Affinity DataIC50: <11nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair