BDBM150607 US10238633, Example 281::US8987249, 281::US9713606, 281

SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C1=CCN2CCOCC2C1

InChI Key InChIKey=CMFKDMUAZSMZET-SIKKGAFYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 150607   

TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150607(US10238633, Example 281 | US8987249, 281 | US97136...)
Affinity DataIC50:  3.30nMT: 2°CAssay Description:The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 ug/ml, respectively), and then activated by mixing in a 1:2 ratio with a Cys...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150607(US10238633, Example 281 | US8987249, 281 | US97136...)
Affinity DataIC50:  3.30nMpH: 6.0 T: 2°CAssay Description:Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin K(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150607(US10238633, Example 281 | US8987249, 281 | US97136...)
Affinity DataIC50:  1.90E+3nMAssay Description:To activate the proenzyme, 5 μl procathepsin K were mixed with 1 ul activation buffer, and incubated at room temperature for 30 min.5 μL te...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150607(US10238633, Example 281 | US8987249, 281 | US97136...)
Affinity DataIC50:  3.30nMAssay Description:The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in a 1:2 ratio with ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin K(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150607(US10238633, Example 281 | US8987249, 281 | US97136...)
Affinity DataIC50:  1.90E+3nMpH: 3.5 T: 2°CAssay Description:Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...More data for this Ligand-Target Pair
In DepthDetails US Patent